Bartholomew Cubbins on Autism Episode 2: Waly et al, Mol Psych 2004
A rough discussion of Waly et al, Mol Psych 2004. Overall, the work is very interesting but the materials and methods description leaves a lot to be desired and the effect on PLM was marginal, often only 2-fold across several orders of magnitude of effector concentration. Further, many questions arise such as the form of the metals (counterion description?) and ensuring that the ionic strength and the pH remained constant across the effector titrations. What would be particularly interesting is comparing this assay (using maybe a mouse neuro line) with a side-by-side animal model experiment.